Brittle Bone Disease (Osteogenesis Imperfecta)
Definition
Osteogenesis imperfecta is a condition causing extremely fragile bones.
Symptoms
All people with OI have weak bones, which makes them susceptible to fractures. Persons with OI are usually below average height ( short stature). However, the severity of the disease varies greatly.
The classic symptoms include:
* Blue tint to the whites of their eyes (blue sclera)
* Multiple bone fractures
* Early hearing loss (deafness)
Because type I collagen is also found in ligaments, persons with OI often have loose joints (hypermobility) and flat feet. Some types of OI also lead to the development of poor teeth.
Symptoms of more severe forms of OI may include:
* Bowed legs and arms
* Kyphosis
* Scoliosis (S-curve spine)
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