Health's Book

Definition

Fragile X syndrome is a genetic condition involving changes in part of the X chromosome. It is the most common form of inherited mental retardation in males and a significant cause of mental retardation in females.

Symptoms

* Hyperactive behavior
* Large body size
* Large forehead or ears with a prominent jaw
* Large testicles (macro-orchidism) after the beginning of puberty
* Mental retardation
* Tendency to avoid eye contact

Family members who have fewer repeats in the FMR1 gene may not have mental retardation, but may have other problems. Women with less severe changes may have premature menopause or difficulty becoming pregnant. Both men and women may have problems with tremors and poor coordination.